signalingpathway相关论文
Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atr
Chronic atrophic gastritis(CAG),a common disease of digestive system,is an extremely important cause of gastric cancer(G......
Cytosolic nucleic acid sensors are critical for sensing nucleic acids and initiating innate immunity during microbial in......
目的:探索研究DNAJB6在部分肝移植肝再生的作用及分子机制。方法:采用DA大鼠作为供体，Lewis大鼠作为受体，构建部分肝移植肝再生模型......
先天性心脏病(congenital heart disease，CHD)是最常见的先天性疾病之一，主要指胎儿于胚胎发育期受到各类异常因素影响而导致的心血......
Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medic
Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,pr......
Objective: This study aims to identify key genes and pathways associated with the molecular biological mechanisms of maj......
UMSCs Attenuate LPS/D-GalN-induced Acute Liver Failure in Mice by Down-regulating the MyD88/NF-κB Pa
Background and Aims: Acute liver failure (ALF) is an inflam-matory process of acute liver cell injury. Mesenchymal stem ......
Corilagin is a gallotannin polyphenolic compound which showed anti-tumor,antioxidant,anti-inflammatory activities.In rec......
Ochratoxin A(OTA),a worldwide mycotoxin found in food and feeds,is a potent nephrotoxin in animals and humans.Porcine ci......
Selenium deficiency facilitates inflammation through the regulation of TLR4 and TLR4-related signali
Selenium (Se) is an essential nutritional trace element that affects the development and function of the reproductive sy......
The retinoid X receptor from mud crab: new insights into its roles in ovarian development and relate
In arthropods,retinoid X receptor (RXR) is a highly conserved nuclear hormone receptor.By forming a heterodimeric comple......
Background: Tilapia is an important freshwater aquaculture species worldwide.In recent years, streptococcal diseases hav......
Interplay between TGF-β1 and IL-1β causes a shift of their signaling activity in grass carp head kid
The aim of this study was to clarify the regulatory mechanisms of IL-1β autostimulation in fish immunity, with particul......
The Involvement of Protease Nexin-1 (PN-1) in the Pathogenesis of Intervertebral Disc (IVD) Degenera
Objective Protease Nexin-1(PN-1)has been found to interact with both extracellular matrix(ECM)and intracellular cartilag......
[Background] Low back pain (LBP) is a common and remitting problem. One of the main cause of LBP is thought to be degene......
Angiotensin-(1-7)decreases the expression of collagen Ⅰ via TGF-β1/Smad2/3 and subsequently inhibits
目的 Previous studies have shown that renin-angiotensin system (RAS) might participate in airway remodeling in asthma.As......
The role of the PI3K/AKT/mTOR protein synthesis pathway in theskeletal muscle atrophy induced by COP
目的 To confirm the role of PI3K/AKT/mTOR protein synthesis pathway in skeletal muscle atrophy induced by chronic obstru......
S897 phosphorylation of EphA2 is indispensable for EphA2-dependent nasopharyngeal carcinoma cell inv
Objective The phosphorylation of EphA2 at serine 897(pS897-EphA2)plays a key role in the ligand-independent functions of......
...
The Ras-Raf-mitogen-activated protein kinase kinase (MEK)1/2-extracellular signal-regulated kinase (ERK)1/2 signaling pa......
BAFF/BAFF-R involved in B lymphocyte proliferation of rats with collagen-induced arthritis via PI3K/
Aim: Rheumatoid arthritis (RA) is a systemic autoimmune disease.B, lymphocyte proliferation and activation are essential......
Activation of endothelial cells by complement activation of the alternative pathway and intervention
Aim: To investigate the effect of complement activation of the alternative pathway on human microvascular endothelial ce......
Aim: To evaluate the drug physical dependence of the ethanol extract of Valeriana jatamansi Jones, which is an anxiolyti......
p38 mitogen-activated protein kinases (p38 MAPK,p38) consist of 4 subunits: p38α,p38β,p38γ and p38δ.They play a well......
MLCK involved in the proliferation and migration of vascular smooth muscle cells induced by IL-8 via
Atherosclerosis(AS)is an important pathological basis of cardiovascular events,and damage caused by AS is an important f......
Identification and characterization of a novel IκB-ε-like gene from Lamprey (Lampetra japonica) with
Nuclear factor of kappa B (NF-κB) is a stimuli-activated transcription factor, regulates the expression of a diverse ar......
Proteome sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal P
The dermal papilla is thought to establish the character and control the size of hair follicle.Inner Mongolia Cashmere g......
Tissue factor pathway inhibitor-1 (TFPI-1) has multiple functions and is involved in atherosclerosis, but its precise ro......
RESEARCH ON EFFECT OF AGEs-RAGE SIGNALING PATHWAY ON MYOCARDIAL FIBROSIS OF TYPE TWO DIABETIC RATS A
Diabetic cardiomyopathy (DCM) is one of the chronic complications of diabetes mellitus (DM), and it is one of the main r......
Differential gene expression and related pathways of fetal skeletal malformations of mice by deoxyni
OBJECTIVE:To screen the differential gene expression and related pathways of fetal skeletal malformations of mice by deo......
...
Although evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG)......
Copper,as an essential trace mineral,could cause diseases such as childhood leukemia at excess levels,but few studies ha......
Objective: Toll/interleukin-1 receptor domain containing protein encoded by E.coli (TepC) is a virulence factor of some ......
Klebsiella pneumoniae lipopolysaccharides induce TNF-α and IL-1β in macrophages via TLR 4-and 2-denp
Patients infected with Klebsiella pneumoniae are always lead to severe inflammatory response.However,little is known on ......
Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by18 PM2.5
Air pollution has been a major environment-related health threat.Most of the studies on PM2.5 toxicity have verified on ......
Objective: To investigate whether cryptotanshinone (CPT) could inhibit VEGF-induced angiogenesis and the effect of CPT o......
Up-Regulation of Urotensin Ⅱ and Its Receptor Contributes to Human Hepatocellular Carcinoma Growth v
Urotensin Ⅱ (UⅡ) and its receptor (UTR) have mitogenic effects on tumor growth.Our previous study demonstrated that th......
Salvianolic acid A attenuates isoproterenol-induced myocardial infarction in mice through PI3K/Akt s
OBJECTIVE To investigate the protective effect of salvianolic acid A (Sal A) on isoproterenol-induced myocardial infarct......
Hedyotis Diffusa Willd Extract Suppresses Colorectal Cancer Growth through Multiple Cellular Pathway
The development of colorectal cancer (CRC) is strongly correlated with the imbalance of various intracellular signal tra......
Down-regulation of β-arrestin2 promotes tumor invasion and indicates poor prognosis of hepatocellula
Aims: β-arrestins, including β-arrestin1 and β-arrestin2, are multifunctional adaptor proteins.Recently, some new rol......
Study of the Protective Mechanisms of Compound Danshen Tablet (Fufang Danshen Pian) against Myocardi
Aim of the study:The study is to research the protective mechanisms of Compound Danshen Tablet (CDT) against myocardial ......
...
Scutellaria Barbata D.Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pa
The pathogenic mechanisms underlying cancer development are complex and heterogeneous,involving multiple cellular signal......
Shenkang Ⅶ Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad,N
This study aimed to explore the protective effects of the traditional Chinese Medicine formula Shenkang Ⅶ recipe (SK-7)......
...
Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoi
...
